Hypoxia inducible factors in hepatocellular carcinoma

Hypoxia inducible factors in hepatocellular carcinoma

Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors. In this review, we describe the current understanding of hypoxia signaling pathway and summarize the expression, function and target genes of hypoxia inducible factors in hepatocellular car...

The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma

Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma (HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy resistance. As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown to activate hypoxia-responsive genes, which are involved in multiple aspects of tumorigenesis and cancer progression...

Hypoxia-inducible factor 1, hepatocellular carcinoma and angiogenesis

Angiogenesis is essential for tumor growth, 1 and it has been shown that anti-angiogenic therapy has been proven to be effective in several cancers such as colorectal cancer 2,3 and hepatocellular carcinoma (HCC). 4 Currently available anti-angiogenic cancer chemotherapy targets the vascular endothelial growth factor (VEGF) pathway by VEGF monoclonal antibody (bevacizumab) 3 or multi-targeted r...

Hypoxia and Hypoxia-Inducible Factors in Leukemias

Despite huge improvements in the treatment of leukemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukemic stem cells (LSCs) within the bone marrow, which are able to self-renew, and therefore reestablish the full tumor. The marrow microenvironment contributes considerably in supporting the protection and developmen...

Hepatocellular Carcinoma in Sheep